Pippali (Piper Longum) Through Ayurvedic and Computational Pharmacology: Drug-Likeness, ADME & Multi-Target Actions

Shama Sharad Khandekar; Manoj Kumar Dash; Manish Patel; Saroj Parhate; Kevendra Gangber

doi:10.5455/AAM.305192

2026, Vol: 15, Issue: 4

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Review Article
Online Published: 08 May 2026

AAM. 2026; 15(4): 791-798

doi: 10.5455/AAM.305192

Pippali (Piper Longum) Through Ayurvedic and Computational Pharmacology: Drug-Likeness, ADME & Multi-Target Actions

Shama Sharad Khandekar, Manoj Kumar Dash, Manish Patel, Saroj Parhate, Kevendra Gangber.

Abstract
Piper longum Linn. (Pippali) is a prominent herb in Ayurvedic medicine, widely used for digestive stimulation, rejuvenation, control of inflammation, metabolic regulation, and antimicrobial effects. This study integrates Ayurvedic pharmacological concepts with computational approaches to evaluate the drug-likeness, ADME (Absorption, Distribution, Metabolism, Excretion) properties, and molecular targets of four key alkaloids—piperine, piperlongumine, pellitorine, and guineensine. Using SwissADME, SwissTargetPrediction, and PubChem databases, these compounds were analyzed for pharmacokinetic suitability and therapeutic potential. The findings demonstrate that these phytochemicals exhibit favourable drug-likeness, good gastrointestinal absorption, and multitarget actions, supporting their traditional uses and providing a foundation for future experimental validation.

Key words: Pippali, Piper longum linn., Computational profiling, Piperine, Network pharmacology, ADME profiling; Drug-likeness; Multi-target action

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Pubmed Style

Khandekar SS, Dash MK, Patel M, Parhate S, Gangber K. Pippali (Piper Longum) Through Ayurvedic and Computational Pharmacology: Drug-Likeness, ADME & Multi-Target Actions. AAM. 2026; 15(4): 791-798. doi:10.5455/AAM.305192

Web Style

Khandekar SS, Dash MK, Patel M, Parhate S, Gangber K. Pippali (Piper Longum) Through Ayurvedic and Computational Pharmacology: Drug-Likeness, ADME & Multi-Target Actions. https://www.aamjournal.in/?mno=305192 [Access: October 11, 2026]. doi:10.5455/AAM.305192

AMA (American Medical Association) Style

Khandekar SS, Dash MK, Patel M, Parhate S, Gangber K. Pippali (Piper Longum) Through Ayurvedic and Computational Pharmacology: Drug-Likeness, ADME & Multi-Target Actions. AAM. 2026; 15(4): 791-798. doi:10.5455/AAM.305192

Vancouver/ICMJE Style

Khandekar SS, Dash MK, Patel M, Parhate S, Gangber K. Pippali (Piper Longum) Through Ayurvedic and Computational Pharmacology: Drug-Likeness, ADME & Multi-Target Actions. AAM. (2026), [cited October 11, 2026]; 15(4): 791-798. doi:10.5455/AAM.305192

Harvard Style

Khandekar, S. S., Dash, . M. K., Patel, . M., Parhate, . S. & Gangber, . K. (2026) Pippali (Piper Longum) Through Ayurvedic and Computational Pharmacology: Drug-Likeness, ADME & Multi-Target Actions. AAM, 15 (4), 791-798. doi:10.5455/AAM.305192

Turabian Style

Khandekar, Shama Sharad, Manoj Kumar Dash, Manish Patel, Saroj Parhate, and Kevendra Gangber. 2026. Pippali (Piper Longum) Through Ayurvedic and Computational Pharmacology: Drug-Likeness, ADME & Multi-Target Actions. Annals of Ayurvedic Medicine, 15 (4), 791-798. doi:10.5455/AAM.305192

Chicago Style

Khandekar, Shama Sharad, Manoj Kumar Dash, Manish Patel, Saroj Parhate, and Kevendra Gangber. "Pippali (Piper Longum) Through Ayurvedic and Computational Pharmacology: Drug-Likeness, ADME & Multi-Target Actions." Annals of Ayurvedic Medicine 15 (2026), 791-798. doi:10.5455/AAM.305192

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style


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