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Original Research 


Regulation of lipids and inflammation by vaisvanara churnam in hypercholesterolemia

Santhi Krishnan, Vidya Sabu, Aswathy IS, Jasmine Peter, Lalpreethi SS, Helen Antony.


Abstract
Conventional ayurvedic herbal formulations exhibited enormous potential effects to ameliorate hypercholesterolemia. Vaisvanara Churnam (VC), a classic conventional ayurvedic formulation useful to correct digestive system disorders. Hypercholesterolemia is induced by oral administration of 1.5% of cholesterol along with cholic acid (0.5%) and treated with VC (450mg/kg) for 60 days in rats. The objective is to decipher the lipid metabolism regulation via reverse cholesterol transport (RCT) and Toll like receptor, (TLR) signalling pathway in high cholesterol diet fed rats. VC for 60 days in cholesterol co-administered rats tapered off the elevated lipid profile, decreased lipogenic enzymes, enhanced RCT and decreased TLR-NFқB expression, maintains the balance of pro and anti-inflammatory cytokines and boost up the excretion of bile acids. VC thus effectively abolished the established hypercholesterolemia and had a conspicuous protective role against atherogenesis.

Key words: Vaisvanara Churnam, Ayurveda, Hypercholesterolemia, RCT, Inflammation


 
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How to Cite this Article
Pubmed Style

Krishnan S, VS, IS A, JP, SS L, Antony H. Regulation of lipids and inflammation by vaisvanara churnam in hypercholesterolemia. AAM. 2023; 12(4): 351-367. doi:10.5455/AAM.86904

Web Style

Krishnan S, VS, IS A, JP, SS L, Antony H. Regulation of lipids and inflammation by vaisvanara churnam in hypercholesterolemia. https://www.aamjournal.in/?mno=86904 [Access: September 13, 2024]. doi:10.5455/AAM.86904

AMA (American Medical Association) Style

Krishnan S, VS, IS A, JP, SS L, Antony H. Regulation of lipids and inflammation by vaisvanara churnam in hypercholesterolemia. AAM. 2023; 12(4): 351-367. doi:10.5455/AAM.86904


Vancouver/ICMJE Style

Krishnan S, VS, IS A, JP, SS L, Antony H. Regulation of lipids and inflammation by vaisvanara churnam in hypercholesterolemia. AAM. (2023), [cited September 13, 2024]; 12(4): 351-367. doi:10.5455/AAM.86904


Harvard Style

Krishnan, S., , . V. S., IS, . A., , . J. P., SS, . L. & Antony, . H. (2023) Regulation of lipids and inflammation by vaisvanara churnam in hypercholesterolemia. AAM, 12 (4), 351-367. doi:10.5455/AAM.86904


Turabian Style

Krishnan, Santhi, Vidya Sabu, Aswathy IS, Jasmine Peter, Lalpreethi SS, and Helen Antony. 2023. Regulation of lipids and inflammation by vaisvanara churnam in hypercholesterolemia. Annals of Ayurvedic Medicine, 12 (4), 351-367. doi:10.5455/AAM.86904


Chicago Style

Krishnan, Santhi, Vidya Sabu, Aswathy IS, Jasmine Peter, Lalpreethi SS, and Helen Antony. "Regulation of lipids and inflammation by vaisvanara churnam in hypercholesterolemia." Annals of Ayurvedic Medicine 12 (2023), 351-367. doi:10.5455/AAM.86904


MLA (The Modern Language Association) Style

Krishnan, Santhi, Vidya Sabu, Aswathy IS, Jasmine Peter, Lalpreethi SS, and Helen Antony. "Regulation of lipids and inflammation by vaisvanara churnam in hypercholesterolemia." Annals of Ayurvedic Medicine 12.4 (2023), 351-367. Print. doi:10.5455/AAM.86904


APA (American Psychological Association) Style

Krishnan, S., , . V. S., IS, . A., , . J. P., SS, . L. & Antony, . H. (2023) Regulation of lipids and inflammation by vaisvanara churnam in hypercholesterolemia. Annals of Ayurvedic Medicine, 12 (4), 351-367. doi:10.5455/AAM.86904


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Annals of Ayurvedic Medicine (AAM) is the organ of ‘Association of Ayurvedic Physicians of India'(AAPI), which is a national representative body of Ayur ... Read more.



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