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Original Research 
AAM. 2012; 1(3): 71-76


Genetic variation at the CXC chemokine IP-10(CXCL10) in parallel with its increased serum level in south-eastern Iranian multiple sclerosis patients

Hossein Karkamandi, Seyed-Mostafa Hosseini-zijoud, Javad Hosseini.

Cited by (2)

Abstract
Aim: Immune system-related factors are important in pathogenesis of multiple sclerosis IP-10 as CXC chemokines are involved in the immune responses. Hence, this study was to investigate the association between multiple sclerosis and serum level of IP-10.
Methods: In this experimental study, blood samples were collected from 100 multiple sclerosis patients and 100 healthy controls on EDTA pre-coated tubes. Demographic data were also collected by a questionnaire which was designed specifically for this study.
Results: Our results showed that serum level of IP-10 was significantly higher in the patients than healthy controls.
We are also showed that relapsing remitting multiple sclerosis )RRMS( patients with a good economical status had elevated IP-10(CXCL10) in compare to median group (P<0.01). The circulating level of IP-10 (CXCL10) was significantly increased in female in compare to male RRMS patients (P<0.01) and in patients who received in female in compare to male RRMS patients (P<0.01) and in patients who received less them 3 years treatment (P<0.01).
Conclusion: Based on the results of this study, it can probably be concluded that serum level of IP-10 have an important role in pathogenesis of multiple sclerosis. It is also worth noting that these factors could probably use as pivotal biological markers in diagnosis and possible treatment factors.

Key words: Multiple sclerosis, IP-10(CXCL10), Polymorphism, chemokine.


 
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This Article Cited By the following articles

The biological functions, structure and sources of CXCL10 and its outstanding part in the pathophysiology of multiple sclerosis.
Neuroimmunomodulation 2014; 21(6): 322-30.

1
 
The Biological Functions, Structure and Sources of CXCL10 and Its Outstanding Part in the Pathophysiology of Multiple Sclerosis
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2
 

How to Cite this Article
Pubmed Style

Karkamandi H, Hosseini-zijoud S, Hosseini J. Genetic variation at the CXC chemokine IP-10(CXCL10) in parallel with its increased serum level in south-eastern Iranian multiple sclerosis patients. AAM. 2012; 1(3): 71-76.


Web Style

Karkamandi H, Hosseini-zijoud S, Hosseini J. Genetic variation at the CXC chemokine IP-10(CXCL10) in parallel with its increased serum level in south-eastern Iranian multiple sclerosis patients. http://www.aamjournal.in/?mno=18969 [Access: May 25, 2018].


AMA (American Medical Association) Style

Karkamandi H, Hosseini-zijoud S, Hosseini J. Genetic variation at the CXC chemokine IP-10(CXCL10) in parallel with its increased serum level in south-eastern Iranian multiple sclerosis patients. AAM. 2012; 1(3): 71-76.



Vancouver/ICMJE Style

Karkamandi H, Hosseini-zijoud S, Hosseini J. Genetic variation at the CXC chemokine IP-10(CXCL10) in parallel with its increased serum level in south-eastern Iranian multiple sclerosis patients. AAM. (2012), [cited May 25, 2018]; 1(3): 71-76.



Harvard Style

Karkamandi, H., Hosseini-zijoud, S. & Hosseini, J. (2012) Genetic variation at the CXC chemokine IP-10(CXCL10) in parallel with its increased serum level in south-eastern Iranian multiple sclerosis patients. AAM, 1 (3), 71-76.



Turabian Style

Karkamandi, Hossein, Seyed-Mostafa Hosseini-zijoud, and Javad Hosseini. 2012. Genetic variation at the CXC chemokine IP-10(CXCL10) in parallel with its increased serum level in south-eastern Iranian multiple sclerosis patients. Annals of Ayurvedic Medicine, 1 (3), 71-76.



Chicago Style

Karkamandi, Hossein, Seyed-Mostafa Hosseini-zijoud, and Javad Hosseini. "Genetic variation at the CXC chemokine IP-10(CXCL10) in parallel with its increased serum level in south-eastern Iranian multiple sclerosis patients." Annals of Ayurvedic Medicine 1 (2012), 71-76.



MLA (The Modern Language Association) Style

Karkamandi, Hossein, Seyed-Mostafa Hosseini-zijoud, and Javad Hosseini. "Genetic variation at the CXC chemokine IP-10(CXCL10) in parallel with its increased serum level in south-eastern Iranian multiple sclerosis patients." Annals of Ayurvedic Medicine 1.3 (2012), 71-76. Print.



APA (American Psychological Association) Style

Karkamandi, H., Hosseini-zijoud, S. & Hosseini, J. (2012) Genetic variation at the CXC chemokine IP-10(CXCL10) in parallel with its increased serum level in south-eastern Iranian multiple sclerosis patients. Annals of Ayurvedic Medicine, 1 (3), 71-76.








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