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Monotherapy with Kutaj Parpati Is Effective in reducing Irritable Bowel Syndrome (IBS) Symptoms – A Randomized controlled, parallel group trial

Manjiri Ranade.

Abstract
Background: Irritable bowel syndrome (IBS) is a disorder that causes diarrhoea, constipation, stomach discomfort and bloating. IBS symptoms are linked to Grahani roga. There are few trials with Kutaj parpati in IBS, but the findings are inconsistent. We tested the null hypothesis that there is no difference between the Kutaj parpati and placebo for improvement of symptoms of IBS.
Materials and Methods: This is a randomized, single blind, placebo control trial. Sample size estimation was done to have power of 80 % and 95% confidence interval. A total of 20 patients were enrolled in the trial who were diagnosed with irritable bowel syndrome according to the ROME 3 criteria. Group A received Kutaj parpati in a dose of 250 mg thrice a day while Group B received placebo. The patient rated the degree of abdominal discomfort, frequency of abdominal discomfort, severity of abdominal bloating, interference with daily activities, and satisfaction with bowel habits on a numeric rating scale (NRS) of 1-10 at three time points: one ,two and three months.
Results: The demographic features of the individuals were similar. The most bothersome symptom was abdominal bloating with numeric rating scale (NRS) of 7.4± 0.942. There was improvement over the three months in other symptoms (Not statistically significant). The statistical significance was achieved (p value 0.00015) with abdominal bloating after three months of therapy.
Conclusion: Kutaj Parpati was beneficial in reducing abdominal bloating in IBS over a three month period; however it did not demonstrate substantial improvement for other symptoms.

Key words: Irritable bowel Syndrome,Kutaj Parpati, Monotherapy


 
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Pubmed Style

Manjiri Ranade. Monotherapy with Kutaj Parpati Is Effective in reducing Irritable Bowel Syndrome (IBS) Symptoms – A Randomized controlled, parallel group trial. AAM. 2021; 10(4): 362-369. doi:10.5455/AAM.84373


Web Style

Manjiri Ranade. Monotherapy with Kutaj Parpati Is Effective in reducing Irritable Bowel Syndrome (IBS) Symptoms – A Randomized controlled, parallel group trial. https://www.aamjournal.in/?mno=84373 [Access: May 07, 2022]. doi:10.5455/AAM.84373


AMA (American Medical Association) Style

Manjiri Ranade. Monotherapy with Kutaj Parpati Is Effective in reducing Irritable Bowel Syndrome (IBS) Symptoms – A Randomized controlled, parallel group trial. AAM. 2021; 10(4): 362-369. doi:10.5455/AAM.84373



Vancouver/ICMJE Style

Manjiri Ranade. Monotherapy with Kutaj Parpati Is Effective in reducing Irritable Bowel Syndrome (IBS) Symptoms – A Randomized controlled, parallel group trial. AAM. (2021), [cited May 07, 2022]; 10(4): 362-369. doi:10.5455/AAM.84373



Harvard Style

Manjiri Ranade (2021) Monotherapy with Kutaj Parpati Is Effective in reducing Irritable Bowel Syndrome (IBS) Symptoms – A Randomized controlled, parallel group trial. AAM, 10 (4), 362-369. doi:10.5455/AAM.84373



Turabian Style

Manjiri Ranade. 2021. Monotherapy with Kutaj Parpati Is Effective in reducing Irritable Bowel Syndrome (IBS) Symptoms – A Randomized controlled, parallel group trial. Annals of Ayurvedic Medicine, 10 (4), 362-369. doi:10.5455/AAM.84373



Chicago Style

Manjiri Ranade. "Monotherapy with Kutaj Parpati Is Effective in reducing Irritable Bowel Syndrome (IBS) Symptoms – A Randomized controlled, parallel group trial." Annals of Ayurvedic Medicine 10 (2021), 362-369. doi:10.5455/AAM.84373



MLA (The Modern Language Association) Style

Manjiri Ranade. "Monotherapy with Kutaj Parpati Is Effective in reducing Irritable Bowel Syndrome (IBS) Symptoms – A Randomized controlled, parallel group trial." Annals of Ayurvedic Medicine 10.4 (2021), 362-369. Print. doi:10.5455/AAM.84373



APA (American Psychological Association) Style

Manjiri Ranade (2021) Monotherapy with Kutaj Parpati Is Effective in reducing Irritable Bowel Syndrome (IBS) Symptoms – A Randomized controlled, parallel group trial. Annals of Ayurvedic Medicine, 10 (4), 362-369. doi:10.5455/AAM.84373








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