E-ISSN 2347-6923 | ISSN 2277-4092
 

Original Research 


Immunological Effect of the drug “Immune”- an Ayurveda medication in COVID-19 patients- A Randomized Control Trial

Sailaja Vani Batchu, Sudha Bala, E. Kalyan kumar, Srinivasa Rao chunchu, Dhanalakshmi Annavarapu.


Abstract
Introduction: The Pandemic of SARS COV-2 continues to be a global health threat which has affected 140 million cases all over the world with 3.01million deaths with the main underlying main cause of raised inflammatory markers. India is well known for the birth of Ayurveda – the potential therapeutic agents have been developed having combination of already proven drugs for research.
Objectives: To measure the effect of drug- “Immune” on the neutralizing antibody levels along with inflammatory markers among mild to moderate symptomatic COVID-19 subjects.
Material and methods: Triple blinded Randomized Controlled Trial was adopted in our study among mild and moderate cases of COVID-19. Two groups- each having 25 subjects were intervened along with standard care of treatment where one was getting the drug immune consisting of Withania somnifera , glycrrhizine gabra , Cederus Deodara and Leptadenia Reticulata in Arka preparation and other were getting placebo which was blinded by labelling as drug A and Drug B. These two groups were followed up for antibody testing and inflammatory markers such as interleukin-6,D-dimer,serum ferritin and lactate dehydrogenase were also assessed.
Results: There was a statistical significant rise in antibody titres(P value<0.05) with drug A compared to drug B which was later revealed to be drug immune and we could also found reduction in inflammatory marker mainly lactate dehydrogenase.
Conclusion: This drug “Immune” proved to be of clinical significance with raised antibody titre and reduction of some of the inflammatory markers. And this can play a pivotal therapeutic agent to reduce the morbidity and mortality associated with SARS COV-2

Key words: COVID-19, Immunological effect, Ayurveda formulation


 
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How to Cite this Article
Pubmed Style

Batchu SV, Bala S, kumar EK, chunchu SR, Annavarapu D, . Immunological Effect of the drug “Immune”- an Ayurveda medication in COVID-19 patients- A Randomized Control Trial. AAM. 2024; 13(2): 93-101. doi:10.5455/AAM.43833


Web Style

Batchu SV, Bala S, kumar EK, chunchu SR, Annavarapu D, . Immunological Effect of the drug “Immune”- an Ayurveda medication in COVID-19 patients- A Randomized Control Trial. https://www.aamjournal.in/?mno=43833 [Access: June 28, 2024]. doi:10.5455/AAM.43833


AMA (American Medical Association) Style

Batchu SV, Bala S, kumar EK, chunchu SR, Annavarapu D, . Immunological Effect of the drug “Immune”- an Ayurveda medication in COVID-19 patients- A Randomized Control Trial. AAM. 2024; 13(2): 93-101. doi:10.5455/AAM.43833



Vancouver/ICMJE Style

Batchu SV, Bala S, kumar EK, chunchu SR, Annavarapu D, . Immunological Effect of the drug “Immune”- an Ayurveda medication in COVID-19 patients- A Randomized Control Trial. AAM. (2024), [cited June 28, 2024]; 13(2): 93-101. doi:10.5455/AAM.43833



Harvard Style

Batchu, S. V., Bala, S., kumar, E. K., chunchu, S. R., Annavarapu, D. & (2024) Immunological Effect of the drug “Immune”- an Ayurveda medication in COVID-19 patients- A Randomized Control Trial. AAM, 13 (2), 93-101. doi:10.5455/AAM.43833



Turabian Style

Batchu, Sailaja Vani, Sudha Bala, E. Kalyan kumar, Srinivasa Rao chunchu, Dhanalakshmi Annavarapu, and . 2024. Immunological Effect of the drug “Immune”- an Ayurveda medication in COVID-19 patients- A Randomized Control Trial. Annals of Ayurvedic Medicine, 13 (2), 93-101. doi:10.5455/AAM.43833



Chicago Style

Batchu, Sailaja Vani, Sudha Bala, E. Kalyan kumar, Srinivasa Rao chunchu, Dhanalakshmi Annavarapu, and . "Immunological Effect of the drug “Immune”- an Ayurveda medication in COVID-19 patients- A Randomized Control Trial." Annals of Ayurvedic Medicine 13 (2024), 93-101. doi:10.5455/AAM.43833



MLA (The Modern Language Association) Style

Batchu, Sailaja Vani, Sudha Bala, E. Kalyan kumar, Srinivasa Rao chunchu, Dhanalakshmi Annavarapu, and . "Immunological Effect of the drug “Immune”- an Ayurveda medication in COVID-19 patients- A Randomized Control Trial." Annals of Ayurvedic Medicine 13.2 (2024), 93-101. Print. doi:10.5455/AAM.43833



APA (American Psychological Association) Style

Batchu, S. V., Bala, S., kumar, E. K., chunchu, S. R., Annavarapu, D. & (2024) Immunological Effect of the drug “Immune”- an Ayurveda medication in COVID-19 patients- A Randomized Control Trial. Annals of Ayurvedic Medicine, 13 (2), 93-101. doi:10.5455/AAM.43833