E-ISSN 2347-6923 | ISSN 2277-4092
 

Original Research 


"In Vitro Evaluation of the Antiplatelet Activity of Paravat Shakrita"

Prakash Kumbar, Naresh Kore.


Abstract
Platelet aggregation, a crucial process in thrombotic disorders, underscores the necessity for effective preventive and therapeutic measures. This study compares the antiplatelet effects of Aspirin, a well-established drug, with Paravat Shakrita, a lesser-known formulation from Ayurvedic texts. It underwent GCMS and microbiological analysis to determine its chemical composition and microbial load. Using an in vitro model with rat blood samples, we conducted a Platelet Aggregation Inhibition Assay. As expected, Aspirin inhibited platelet aggregation in a concentration-dependent manner, consistent with its known mechanism. Despite limited documentation, Paravat Shakrita exhibited potent antiplatelet properties, also showing dose-dependent effects. Interestingly, Paravat Shakrita demonstrated comparable or even superior effects at higher concentrations compared to Aspirin. The IC50 values revealed similar inhibitory potency between Paravat Shakrita and Aspirin. This comparison unveiled distinct mechanisms of action, providing various therapeutic options against platelet-mediated thrombosis. While promising, further investigation is crucial to understand Paravat Shakrita's mechanism, ensure its safety, and determine its clinical significance.

Key words: Thrombotic disorders, Platelet Aggregation Inhibition Assay, Concentration-response relationships, Inhibitory potency


 
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How to Cite this Article
Pubmed Style

PK, Kore N, . "In Vitro Evaluation of the Antiplatelet Activity of Paravat Shakrita". AAM. 2024; 13(2): 125-130. doi:10.5455/AAM.193273


Web Style

PK, Kore N, . "In Vitro Evaluation of the Antiplatelet Activity of Paravat Shakrita". https://www.aamjournal.in/?mno=193273 [Access: June 28, 2024]. doi:10.5455/AAM.193273


AMA (American Medical Association) Style

PK, Kore N, . "In Vitro Evaluation of the Antiplatelet Activity of Paravat Shakrita". AAM. 2024; 13(2): 125-130. doi:10.5455/AAM.193273



Vancouver/ICMJE Style

PK, Kore N, . "In Vitro Evaluation of the Antiplatelet Activity of Paravat Shakrita". AAM. (2024), [cited June 28, 2024]; 13(2): 125-130. doi:10.5455/AAM.193273



Harvard Style

, P. K., Kore, N. & (2024) "In Vitro Evaluation of the Antiplatelet Activity of Paravat Shakrita". AAM, 13 (2), 125-130. doi:10.5455/AAM.193273



Turabian Style

, Prakash Kumbar, Naresh Kore, and . 2024. "In Vitro Evaluation of the Antiplatelet Activity of Paravat Shakrita". Annals of Ayurvedic Medicine, 13 (2), 125-130. doi:10.5455/AAM.193273



Chicago Style

, Prakash Kumbar, Naresh Kore, and . ""In Vitro Evaluation of the Antiplatelet Activity of Paravat Shakrita"." Annals of Ayurvedic Medicine 13 (2024), 125-130. doi:10.5455/AAM.193273



MLA (The Modern Language Association) Style

, Prakash Kumbar, Naresh Kore, and . ""In Vitro Evaluation of the Antiplatelet Activity of Paravat Shakrita"." Annals of Ayurvedic Medicine 13.2 (2024), 125-130. Print. doi:10.5455/AAM.193273



APA (American Psychological Association) Style

, P. K., Kore, N. & (2024) "In Vitro Evaluation of the Antiplatelet Activity of Paravat Shakrita". Annals of Ayurvedic Medicine, 13 (2), 125-130. doi:10.5455/AAM.193273