E-ISSN 2347-6923 | ISSN 2277-4092
 

Original Research 


A Neoteric Approach to Assess the Potential of Synergistic Effect of Curcumin and Resveratrol in Cholesterol Regulations: An Experimental Study

Yogesh Sagotia, Kalpana Dabhade, Mitesh Makwana, Swapnil Sagotia.


Abstract
Background: Cholesterol in human body has structural as well metabolic implications. In moderation, it exerts favorable effects upon the human body but, beyond the normal limits may result in undesired pathological conditions such as atherosclerosis. The polyphenols, Curcumin and Resveratrol have been reported to have a positive impact on cholesterol regulation evident from previous research studies. However, there has been no evidence on the conjugate effects of both Resveratrol and Curcumin in the expression levels of CYP7A1 and its enzymatic activity.
Objectives: The aim of the current study was to evaluate the potential synergistic effects of Curcumin and Resveratrol in cholesterol regulation.
Methodology: The present experimental study was carried out to assess the synergistic effects of Curcumin and Resveratrol in cholesterol regulation in Swiss mice on 8 weeks treatment. Co-administration of Curcumin-Resveratrol in study group and Atorvastatin in standard control group was done for same duration.
Results: Results demonstrated that the Co-administration of Curcumin-Resveratrol was effective in regulation of cholesterol in comparison with individual Curcumin or Resveratrol treatment as well as equivalent to standard control Atorvastatin.
Conclusion: The potential synergistic effects of Curcumin and Resveratrol in cholesterol regulation are evident from the present study than their individual influences.

Key words: Atherosclerosis, Cholesterol regulation, Curcumin, Polyphenols Resveratrol


 
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How to Cite this Article
Pubmed Style

Sagotia Y, Dabhade K, Makwana M, Sagotia S, . A Neoteric Approach to Assess the Potential of Synergistic Effect of Curcumin and Resveratrol in Cholesterol Regulations: An Experimental Study. AAM. 2024; 13(2): 113-124. doi:10.5455/AAM.170684


Web Style

Sagotia Y, Dabhade K, Makwana M, Sagotia S, . A Neoteric Approach to Assess the Potential of Synergistic Effect of Curcumin and Resveratrol in Cholesterol Regulations: An Experimental Study. https://www.aamjournal.in/?mno=170684 [Access: June 28, 2024]. doi:10.5455/AAM.170684


AMA (American Medical Association) Style

Sagotia Y, Dabhade K, Makwana M, Sagotia S, . A Neoteric Approach to Assess the Potential of Synergistic Effect of Curcumin and Resveratrol in Cholesterol Regulations: An Experimental Study. AAM. 2024; 13(2): 113-124. doi:10.5455/AAM.170684



Vancouver/ICMJE Style

Sagotia Y, Dabhade K, Makwana M, Sagotia S, . A Neoteric Approach to Assess the Potential of Synergistic Effect of Curcumin and Resveratrol in Cholesterol Regulations: An Experimental Study. AAM. (2024), [cited June 28, 2024]; 13(2): 113-124. doi:10.5455/AAM.170684



Harvard Style

Sagotia, Y., Dabhade, K., Makwana, M., Sagotia, S. & (2024) A Neoteric Approach to Assess the Potential of Synergistic Effect of Curcumin and Resveratrol in Cholesterol Regulations: An Experimental Study. AAM, 13 (2), 113-124. doi:10.5455/AAM.170684



Turabian Style

Sagotia, Yogesh, Kalpana Dabhade, Mitesh Makwana, Swapnil Sagotia, and . 2024. A Neoteric Approach to Assess the Potential of Synergistic Effect of Curcumin and Resveratrol in Cholesterol Regulations: An Experimental Study. Annals of Ayurvedic Medicine, 13 (2), 113-124. doi:10.5455/AAM.170684



Chicago Style

Sagotia, Yogesh, Kalpana Dabhade, Mitesh Makwana, Swapnil Sagotia, and . "A Neoteric Approach to Assess the Potential of Synergistic Effect of Curcumin and Resveratrol in Cholesterol Regulations: An Experimental Study." Annals of Ayurvedic Medicine 13 (2024), 113-124. doi:10.5455/AAM.170684



MLA (The Modern Language Association) Style

Sagotia, Yogesh, Kalpana Dabhade, Mitesh Makwana, Swapnil Sagotia, and . "A Neoteric Approach to Assess the Potential of Synergistic Effect of Curcumin and Resveratrol in Cholesterol Regulations: An Experimental Study." Annals of Ayurvedic Medicine 13.2 (2024), 113-124. Print. doi:10.5455/AAM.170684



APA (American Psychological Association) Style

Sagotia, Y., Dabhade, K., Makwana, M., Sagotia, S. & (2024) A Neoteric Approach to Assess the Potential of Synergistic Effect of Curcumin and Resveratrol in Cholesterol Regulations: An Experimental Study. Annals of Ayurvedic Medicine, 13 (2), 113-124. doi:10.5455/AAM.170684