A randomised controlled study to evaluate the comparative efficacy of Ashwagandha (Withania somnifera) and Madhuyashti (Glycyrrhiza glabra) in the management of Ksheena shukra (Oligozoospermia)

Sanjay K Tiwari; Atal Bihari Trivedi

doi:10.5455/AAM.153596

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AAM. 2025; 14(1): 18-29

doi: 10.5455/AAM.153596

A randomised controlled study to evaluate the comparative efficacy of Ashwagandha (Withania somnifera) and Madhuyashti (Glycyrrhiza glabra) in the management of Ksheena shukra (Oligozoospermia)

Sanjay K Tiwari, Atal Bihari Trivedi.

Abstract
Sperm is a vital component of the body because it is used for reproduction, the process of creation of the next generation. Male infertility can cause the inability to reach conception, it can be due to a defect in semen parameters, anatomical defects in the reproductive tract, hormonal issues, etc. A sperm count below 15 million sperm/mL is considered a state of oligozoospermia. Ksheenashukra is the situation in which both the quantity and quality of shukra dhatu are reduced. Oligozoospermia is synonymous with Ksheenashukra, one of the eight varieties of shukradushti described in the classics and it is due to the vitiation of Vata-pitta. In light of this, efforts were made to treat Ksheenashukra (Oligozoospermia) at the OPD level. This study was made to assess the efficacy and compare the role of Madhuyashti churna (3gm BD) and Ashwagandha churna (3gm BD) on seminal parameters with anupana of milk and after kostha shodhana with Haritakyadi churna (one-time dose of 10gm on day 1 only). The trial of these drugs was done on 60 subjects (30 in each group) and assessment of the subjects on the selected criteria was analyzed. The pre-treatment total sperm count levels were 10.08 and 11.21 mil/mL which rises to 17.14 and 20.53 mil/mL post-treatment in Group A and B respectively. The outcome of the study shows that both drugs are effective in the management of Ksheenshukra. But in certain aspects, Ashwagandha churna has outperformed Madhuyashti churna.

Key words: Ksheenshukra, Shukra Kshaya, Shukrakshaya, Ksheenretas, Oligozoospermia, Vajikarana.

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Pubmed Style

Tiwari SK, Trivedi AB. A randomised controlled study to evaluate the comparative efficacy of Ashwagandha (Withania somnifera) and Madhuyashti (Glycyrrhiza glabra) in the management of Ksheena shukra (Oligozoospermia). AAM. 2025; 14(1): 18-29. doi:10.5455/AAM.153596

Web Style

Tiwari SK, Trivedi AB. A randomised controlled study to evaluate the comparative efficacy of Ashwagandha (Withania somnifera) and Madhuyashti (Glycyrrhiza glabra) in the management of Ksheena shukra (Oligozoospermia). https://www.aamjournal.in/?mno=153596 [Access: February 13, 2025]. doi:10.5455/AAM.153596

AMA (American Medical Association) Style

Tiwari SK, Trivedi AB. A randomised controlled study to evaluate the comparative efficacy of Ashwagandha (Withania somnifera) and Madhuyashti (Glycyrrhiza glabra) in the management of Ksheena shukra (Oligozoospermia). AAM. 2025; 14(1): 18-29. doi:10.5455/AAM.153596

Vancouver/ICMJE Style

Harvard Style

Tiwari, S. K. & Trivedi, . A. B. (2025) A randomised controlled study to evaluate the comparative efficacy of Ashwagandha (Withania somnifera) and Madhuyashti (Glycyrrhiza glabra) in the management of Ksheena shukra (Oligozoospermia). AAM, 14 (1), 18-29. doi:10.5455/AAM.153596

Turabian Style

Tiwari, Sanjay K, and Atal Bihari Trivedi. 2025. A randomised controlled study to evaluate the comparative efficacy of Ashwagandha (Withania somnifera) and Madhuyashti (Glycyrrhiza glabra) in the management of Ksheena shukra (Oligozoospermia). Annals of Ayurvedic Medicine, 14 (1), 18-29. doi:10.5455/AAM.153596

Chicago Style

Tiwari, Sanjay K, and Atal Bihari Trivedi. "A randomised controlled study to evaluate the comparative efficacy of Ashwagandha (Withania somnifera) and Madhuyashti (Glycyrrhiza glabra) in the management of Ksheena shukra (Oligozoospermia)." Annals of Ayurvedic Medicine 14 (2025), 18-29. doi:10.5455/AAM.153596

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